Fertility of Interchange Heterozygotes inTriticum DurumDesf

Fertility in balanced heterozygotes for a familial centric fusion translocation, t(DgDg).

Detection of phenylketonuric heterozygotes.

Estimation of plasma phenylalanine and tyrosine by an abridged (30 mm) column chromatography procedure was assessed. Plasma phenylalanine and tyrosine concentrations, determined in 112 phenylketonuric obligate heterozygotes and in 88 normal controls, did not differ significantly from other reported series in which the data were obtained by column chromatography. All these series were combined a...

McArdle's Disease Heterozygotes

Two daughters of a propositus with documented McArdle's disease were shown by enzyme assay, gel electrophoresis, and immunoblotting to be partially deficient in skeletal muscle phosphorylase and, presumably, heterozygous for the trait. Both exhibited only the adult form of the skeletal muscle isozyme. By 31P-nuclear magnetic resonance, both heterozygotes showed a greater production of acid duri...

Beermann, W

Inversion polymorphism is very common in Diptera (Da Cunha 1955). Its occurrence is generally interpreted as an effect of heterosis. The inversion heterozygotes have a selective advantage over the homozygotes. The relative selective value of the genotype depends on the viability and fertility of the phenotype it determines. Hitherto in the discussion of the inversion heterosis the problem of re...

’s syndrome heterozygotes in Japan

Werner’s syndrome is an autosomal recessive disease that causes premature ageing accompanied by an increased susceptibility to cancer. The causative gene (W R N) codes for a DNA helicase. Worldwide, 1200 patients have been reported from 1904 to 1996; 845 from Japan. Patients are distributed all over Japan. But how widely distributed is the mutated WRN gene in the general population? We previous...